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First ESC Clinical Trials to BeginFollow

#1 Jan 23 2009 at 8:48 AM Rating: Excellent
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The FDA has just passed approval for the first ever embryonic stem cell trials on human beings. The company in question plans to test ESC therapies on patients with spinal cord injuries. In previous years, scientists have partially restored movement to rats with spinal injuries using ESC derived treatments so this could turn into something good.

There's a little debate over whether the timing of the FDA approval is purely coincidental or if the FDA acted on what will probably be a more welcoming attitude from the administration but I honestly don't really care. Obama plans to allow for federal funding in ESC research (beyond the few cell lines Bush allowed) and a warmer reception from the government combined with expanding research has great potential. I'm pretty excited about this.
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#2 Jan 23 2009 at 8:57 AM Rating: Good
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Time to start stocking up on your zombie supplies.
#3 Jan 23 2009 at 9:05 AM Rating: Excellent
The science lover in me is very happy today.

#4 Jan 23 2009 at 9:34 AM Rating: Excellent
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Rescinding Bush's stem cell policy should have been a Day 1 executive order. Hopefully it comes soon.

#5 Jan 23 2009 at 10:29 AM Rating: Excellent
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I agree. He said he thought it should come through Congressional action and, as we've seen, Congress is willing to pass legislation making the funding available. But I'm not sure why Obama wants it to come through Congress rather than by executive order. There may be a good legal reason for it but I don't know what it is.
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#6 Jan 23 2009 at 2:16 PM Rating: Excellent
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#7 Jan 23 2009 at 2:21 PM Rating: Good
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Jophiel wrote:
But I'm not sure why Obama wants it to come through Congress rather than by executive order


Inclusion? He may need to make some unpopular executive decisions in the future, so if he includes congress on the easy decisions will that not buy him political collatoral later on?

Or is that not how the US works? Assume its a silly brit asking (not far wrong if you do ..) Smiley: smile
#8 Jan 23 2009 at 2:25 PM Rating: Good
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Mistress GwynapNud wrote:
Jophiel wrote:
But I'm not sure why Obama wants it to come through Congress rather than by executive order


Inclusion? He may need to make some unpopular executive decisions in the future, so if he includes congress on the easy decisions will that not buy him political collatoral later on?

Or is that not how the US works? Assume its a silly brit asking (not far wrong if you do ..) Smiley: smile

It could be it. It would still be nice if he merely cancelled GWB's order right now, and then encouraged congress to draft the bill to actually appropriate the funds.

#9 Jan 24 2009 at 1:14 AM Rating: Excellent
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AshOnMyTomatoes wrote:
Time to start stocking up on your zombie supplies.


I ordered the Zombie Survival Guide after seeing a picture of Amy Winehouse. I'm ready for the Zombie Apocalypse at this point.
#10 Jan 24 2009 at 5:00 AM Rating: Good
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Congress represents the people. (Stop laughing, they do, at least the ones that pay campaign contributions.)
Presidents come and go, a congressional action/law is a "bit" harder to remove.

Joph nice avatar of Baltimore native Johnny Eck.
#11 Jan 26 2009 at 11:00 AM Rating: Good
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The One and Only Poldaran wrote:
AshOnMyTomatoes wrote:
Time to start stocking up on your zombie supplies.


I ordered the Zombie Survival Guide after seeing a picture of Amy Winehouse. I'm ready for the Zombie Apocalypse at this point.


This is an excellent book and I would recommend it to anyone looking to survive the zombie apocalypse.
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#12 Jan 26 2009 at 12:36 PM Rating: Excellent
I'm fully prepared for the Zombie Apocalypse, have been ever since the first time I read the Zombie Survival Guide. I've got a shelter in the woods stocked with several .22 caliber rifles and thousands of rounds of ammunition. Try as they might, those zeds ain't gettin' nowhere near me and mine!


I'm still making preparations to defend myself against the coming robot uprising. Hopefully the robot uprising and the zombie apocalypse don't happen at the same time; sure there's a chance that the zeds and the bots might fight amongst themselves, but I don't think the robots are dumb enough to keep attack zeds, and the zeds really won't care what the metal not-foods are doing. I shudder at the thought.


As for the new ESC funding... Smiley: yippee This is something that I feel should have been done eight years ago. Damn conservative moralists will be the first to fall in the zombie apocalypse. Don't hesitate to shoot her in the head, she's not your mother anymore!
#13 Jan 26 2009 at 2:30 PM Rating: Good
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There may be a good legal reason for it but I don't know what it is.


It's hard to to work big pharma giveaways into an executive order. Sorry, that's the real answer.
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#14 Jan 26 2009 at 4:05 PM Rating: Excellent
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Smasharoo wrote:
It's hard to to work big pharma giveaways into an executive order. Sorry, that's the real answer.
Could be. However, the original bill that passed Congress (and was vetoed by Bush) didn't include anything aside from allowing federal funding for ESC.

There's a tax break bill being floated for stem cell research (written by Senator Vitter (R-LA)) but its language would exclude embryonic stem cell research.

We'll find out when the first bills get drafted up in Congress, I suppose.
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#15 Jan 26 2009 at 4:07 PM Rating: Default
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trickybeck wrote:
It could be it. It would still be nice if he merely cancelled GWB's order right now, and then encouraged congress to draft the bill to actually appropriate the funds.


Not likely to happen. The Democrat way is to open up very large areas of legislation, and then provide grants/funds within that umbrella to things that they know the public might not think too highly of if the specifics were known. Overturning Bush's executive order is essentially taking a stance of support on chopping up unborn human babies and using them for medical research. Not a terrifically popular position.

It's much much much easier to just slip the removal of that restriction into a broad piece of legislation. One that does not address embryonic stem cells specifically, but just defines qualifications for new stem cell research without any restrictions on the type of stem cells. That way you don't ever have to stand at a podium and say you're funding the harvesting of new embryos for stem cell research.
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#16 Jan 26 2009 at 4:08 PM Rating: Default
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Lol. While typing Joph just provided an example of exactly what I was talking about! Nice timing... ;)
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#17 Jan 26 2009 at 4:19 PM Rating: Excellent
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gbaji wrote:
Overturning Bush's executive order is essentially taking a stance of support on chopping up unborn human babies and using them for medical research. Not a terrifically popular position.
Come again? I haven't seen a poll yet where more people were against ESC than for it. And the numbers for it have always been 50%+. Of course, most people are probably smart enough not to describe it as chopping up unborn human babies so maybe that's your disconnect.
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It's much much much easier to just slip the removal of that restriction into a broad piece of legislation.
The last piece of legislation regarding this was specifically about opening funding for ESC and everyone and their dog knew it was specifically about opening funding for ESC. I don't know... were you sleeping back in '07 when this bill passed through Congress and was vetoed? There was absolutely no question what the bill was about.
gbaji wrote:
One that does not address embryonic stem cells specifically, but just defines qualifications for new stem cell research without any restrictions on the type of stem cells.
HR Bill 3 wrote:
AN ACT

To amend the Public Health Service Act to provide for human embryonic stem cell research.
Yeah. Subtle Smiley: dubious

Edited, Jan 26th 2009 6:21pm by Jophiel
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#18 Jan 26 2009 at 4:48 PM Rating: Good
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Quote:
chopping up unborn human babies


Chopping up human babies that have already been born is the more popular option judging by recent events.

Apparently its a productive and mature way of solving land disputes.
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#19 Jan 26 2009 at 5:10 PM Rating: Default
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Jophiel wrote:
Come again? I haven't seen a poll yet where more people were against ESC than for it. And the numbers for it have always been 50%+.


Not looking hard enough?

Quote:
Of course, most people are probably smart enough not to describe it as chopping up unborn human babies so maybe that's your disconnect.


Bingo! We have a winner...


That's why most polls come out closer to 50/50. When you don't tell people that "Embryonic Stem Cell research" means you're destroying unborn human embryos to use them for the research, the issue polls much higher than it does if you do.


Would you agree with the statement that people are more likely to oppose ESC research funding when they know more about what it actually involves? I'm not making any specific point about the rightness nor wrongness of that, but just pointing out that this is why Obama might avoid directly acting and prefer to let the issue slip through legislation.
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#20 Jan 26 2009 at 5:17 PM Rating: Excellent
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Every time I see this thread I keep thinking to myself "Why is Jophiel talking about Electronic Speed Controllers"

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#21 Jan 26 2009 at 5:20 PM Rating: Excellent
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gbaji wrote:
Jophiel wrote:
Come again? I haven't seen a poll yet where more people were against ESC than for it. And the numbers for it have always been 50%+.


Not looking hard enough?



Real Election Results

gbaji wrote:
When you don't tell people that "Embryonic Stem Cell research" means you're destroying unborn human embryos to use them for the research, the issue polls much higher than it does if you do.


And when you leave out the fact that the embryos used aren't unborn human fetuses, they are biological waste waiting to be disposed of, they poll much lower.

Edited, Jan 26th 2009 8:21pm by TirithRR
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#22 Jan 26 2009 at 5:23 PM Rating: Excellent
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Yeah, I guess I stopped finding policy polling relevant after going back four years so I stopped looking that far back. 'Grats on that poll from '04 though.
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That's why most polls come out closer to 50/50. When you don't tell people that "Embryonic Stem Cell research" means you're destroying unborn human embryos to use them for the research, the issue polls much higher than it does if you do.
Really? Examples?
Pew Research in August '07 wrote:
"All in all, which is more important: conducting stem cell research that might result in new medical cures, or not destroying the potential life of human embryos involved in this research?"

Stem Cell Research: 51%
Not Destroying Potential Life: 35%
Unsure: 14%
gbaji wrote:
Would you agree with the statement that people are more likely to oppose ESC research funding when they know more about what it actually involves?
I think most people are already fairly aware of what it involves. And that, if told about it in greater detail, would be more willing to support it rather than less.
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#23 Jan 26 2009 at 5:37 PM Rating: Excellent
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Smiley: laughSmiley: laughSmiley: laugh

I just looked up the actual questioning from Gbaji's poll*. It's wildly inaccurate, stating that "The live embryos would be destroyed in their first week of development to obtain these cells." This reflect either a tremendous willingness to lie in your poll in order to get the answers you want or else a tremendous ignorance regarding IVF. The process of fertilizing the eggs, implanting them in the mother, waiting to see if they take, and then determining what to do with the extras (provided they're not needed because the first ones didn't take) is longer than a week process. This couldn't possibly be because the questions were written by the Secretariat for Pro-Life Activities of the U.S. Conference of Catholic Bishops.

Yes, Gbaji, you're right. When people are given horribly misleading polling questions, they don't support ESC.

Here's an old poll but it's the one I saw which most accurately describes what's going on:
ABC News/Washing Post, June 2001 wrote:
"Sometimes fertility clinics produce extra fertilized eggs, also called embryos, that are not implanted in a woman's womb. These extra embryos either are discarded, or couples can donate them for use in medical research called stem cell research. [Rotate:] Some people support stem cell research, saying it's an important way to find treatments for many diseases. Other people oppose stem cell research, saying it's wrong to use any human embryos for research purposes. What about you? Do you support or oppose stem cell research?"

Support: 63%
Oppose: 33%
No Opinion: 4%


*Whoops, Gbaji cites a 8/04 poll whereas mine is a 5/05 poll. Still, it's the same polling firm running a poll for the same U.S. Conference of Catholic Bishops so there's not much reason to think that the questions changed all that much.

Edited, Jan 26th 2009 7:59pm by Jophiel
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#24 Jan 26 2009 at 6:18 PM Rating: Default
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Jophiel wrote:
Really? Examples?
Pew Research in August '07 wrote:
"All in all, which is more important: conducting stem cell research that might result in new medical cures, or not destroying the potential life of human embryos involved in this research?"

Stem Cell Research: 51%
Not Destroying Potential Life: 35%
Unsure: 14%



The poll question includes a false dilemma Joph. They're asked to balance "stem cell research" (not just embryonic) against not destroying human embryos. Given that most forms of stem cell research do not involve destroying human embryos, the question lends itself to false results. Since the two options are not clearly opposites (ie: do research using ESC, or don't do research using ESC), it's incorrect to interpret the results as though this is the question being asked (which is exactly what you and everyone else does).


Also, this poll does not ask the more relevant question about whether we should fund this research with federal money. The Bush order didn't make it illegal to do research with embryonic stem cells, it just didn't fund that research with public money. Since that's the actual question here (should Obama fund ESC with taxpayer dollars or not), don't you think that's the more relevant question?

The report I linked was a poll result in which that question was asked. Yours, despite being newer and from a fancy organization, fails to actually address the question at hand (shocker!)...

Edited, Jan 26th 2009 6:20pm by gbaji
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#25 Jan 26 2009 at 6:28 PM Rating: Good
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gbaji wrote:

Also, this poll does not ask the more relevant question about whether we should fund this research with federal money.
I think the better question would be something like this:

Should federal funding for human embryonic stem cell research be withheld?


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#26 Jan 26 2009 at 6:36 PM Rating: Default
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Jophiel wrote:
It's wildly inaccurate, stating that "The live embryos would be destroyed in their first week of development to obtain these cells." This reflect either a tremendous willingness to lie in your poll in order to get the answers you want or else a tremendous ignorance regarding IVF.


Huh? Are you arguing that had they stated that the cells could be harvested up to 6 weeks after the embryo first formed that you'd get lower numbers? Really? Cause I'd assume that limiting the time to the first week of embryonic development would tend to make people more ok with stem cell harvesting, not less...

Quote:
The process of fertilizing the eggs, implanting them in the mother, waiting to see if they take, and then determining what to do with the extras (provided they're not needed because the first ones didn't take) is longer than a week process.


They're talking about how long after the cluster of cells ceases to be a blastocyst and becomes an embryo Joph. It was pretty obvious from the question. I'm not sure of the exact techniques and timeline involved, but clearly if you're harvesting embryonic stem cells and the embryonic phase lasts about 6 weeks in humans, then you have about 6 weeks to do the harvesting. I'm not sure if all harvesting is actually done in the first week or not, but I don't see how the question at all biases the results towards opposition of the harvesting.


Not like omitting key details like whether we're supporting funding or just research and whether we think research in the entire field of stem cells is more important than protecting embryos. You know. Like the questions in the Pew survey...



The point is that when people are told exactly what is going on, they are less likely to support funding for embryonic stem cell research. Are you arguing that stem cells *aren't* harvested in the first week of embryonic development? Or that if you harvest them later, this will make people more likely to accept it? What exact information in that question was inaccurate?
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