I've been watching an interview of Stephen Fry (http://en.wikipedia.org/wiki/Stephen_Fry) by Mark Lawson on BBC4, part of a series to commemorate his 50th birthday. He elaborately answers every quetion asked of him (in his usual ridiculously well educated stream of consciousness fashion). The topics range from his hidden homosexuality to his depression and his hatred of criticism.
When talking about his mental illness he describes self-pity as the worst, most destructive, all consuming emotion possible for a person to have. I thought that was pretty insightful.
You could say rage and despair would be pretty high up there as well. I suppose it's harder to approach someone and (sympathetically, supportively) tell them to get over themselves, than it is to tell them to relax or cheer up.
Edited, May 21st 2008 8:38pm by Youshutup