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#52 May 15 2008 at 11:33 AM Rating: Decent
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Unless the EU and Canadian governments are just trying to sell books, hmm?


I don't think you really want government reaction to PR campaigns to be the standard for scientific proof, do you?

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#53 May 15 2008 at 11:53 AM Rating: Good
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Smasharoo wrote:
I think you missed the part showing a link to causality.


Follow the flow chart in the pretty diagram.

Endocrine disruptors in, Testicular cancer and infertility out.

The problem for me is not finding any, it's just drowning in the amount of scientific research in the area. I'm not a scientist, it's not my area, I don't have all the best highlights of the papers on Xenohormones bookmarked.

I've seen/heard several well conducted and thorough interviews/documentaries on the subject. These spanned at least a decade, and came from widely ranging reasearch sources from all over the globe. Read a couple of books, one of which is out on loan, and the other of which has 17 pages of scientific references in the back, and I don't have a scanner.

You can have the Website instead. It doesn't say so there, I guess they don't want to scare off "ordinary people" but two of the authors are research Drs. There's plenty of links to follow from that site.


Lets see if you like this one... it's just a teeny bit of a very large picture.
Quote:
Susiarjo, M, TJ Hassold, E Freeman and PA Hunt. 2007. Bisphenol A Exposure In Utero Disrupts Early Oogenesis in the Mouse. PLoS Genetics, 3(1): e5. doi:10.1371/journal.pgen.0030005.

Experiments with pregnant mice reveal that exposure to doses of bisphenol A (BPA) within the range of common human exposures causes chromosomally abnormal grandchildren.


This effect is possible because female mammals-- including mice and humans-- form their eggs while still in their mother's womb. Thus when a 'grandmother' mouse is exposed to bisphenol A, not only are her direct progeny exposed, but also the eggs that will become her grandchildren.

The exposure to BPA during pregnancy disturbs early egg development in the unborn female fetuses. When these fetuses reach adulthood, the perturbations are translated into an increase in chromosomally-abnormal eggs and embryos.

Chromosome abnormalities are the largest known cause of spontaneous miscarriage in people.

These findings reveal a second major impact of low level BPA on chromosomes. Previous work has shown that BPA exposure during late stages of egg development cause errors in chromosome allocation, a result called aneuploidy. This new research shows that egg formation is also vulnerable at very early stages, while the eggs are being formed within a fetus.

In commentary (Scrambling Eggs in Plastic Bottles) published along with Susiarjo et al., two scientific experts in the field conclude "these observations represent the most convincing demonstration to date that environmental exposures may affect meiotic processes in mammals."

They divided these females (exposed in the womb) into two groups. In one, they examined the females' eggs, once those females reached the age of 4-5 weeks. The other group of females were mated with normal males and the embryos were evaluated for aneuploidy. Their data revealed that as many as 40% of eggs and embryos from females exposed to BPA in utero may be chromosomally abnormal. In contrast, the rate of aneuploidy in eggs and embryos of laboratory mice is normally less than 1%. The difference is highly significant (p < 0.001).



Edited, May 15th 2008 4:08pm by Aripyanfar
#54 May 15 2008 at 2:56 PM Rating: Good
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#55 May 17 2008 at 6:20 AM Rating: Decent
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Firstly Annabella hit the transgendered nail on the head.

Secondly the story I linked I think it is safe to say that the parents were dealing with a rather extreme case and had absolutely no clue what to do. Money a expert in the field at the time came in and told them what to do and they did it thinking it would be in the best interests of the childs happiness. So doing what is possibly viewed as best, and sitting back and hands off approach can be separate.

Also kind of a cautionary tale that reinforces Annabella's statement.
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#56 May 17 2008 at 8:04 AM Rating: Decent
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Lets see if you like this one


I'd like one that shows a causal link to effects in humans.

Or, at this point, a casual ling to effects in humans.


Their data revealed that as many as 40% of eggs and embryos from females exposed to BPA in utero may be chromosomally abnormal.


The words "as many" and "may" here makes this scientifically worthless.

Do you see why?

I'm not saying it's impossible BPA is dangerous. I am saying there is nothing currently establishing a causal link to it harming *people*. There is, however, an alarmist lobbying group actively working to have it banned.

It may turn out that they're right. Right now all that can accurately be said is that they are afraid. Fear of course, is more than enough to move governments to take regulatory action. It's more required than science for political effect.



Edited, May 17th 2008 12:06pm by Smasharoo
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Disclaimer:

To make a long story short, I don't take any responsibility for anything I post here. It's not news, it's not truth, it's not serious. It's parody. It's satire. It's bitter. It's angsty. Your mother's a *****. You like to jack off dogs. That's right, you heard me. You like to grab that dog by the bone and rub it like a ski pole. Your dad? Gay. Your priest? Straight. **** off and let me post. It's not true, it's all in good fun. Now go away.

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