I would recommend Opera, but I learned recently that both Opera and IE are vulnerable to the Virtumonde malware (apparently it automatically loads through advertisements). I got it and it took a good couple days to remove it (It hid itself in my system restore files).
While Opera never let it do anything (it does block all ads and such), Spybot and AVG constantly popped up about the .dll files that Virtumonde was spreading around.
Spybot, AVG, and a System Restore file purge were enough to remove it though. Virtumonde is just constant targeted popup program.
Edited, Dec 17th 2008 6:13pm by TirithRR
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Can't sleep, clown will eat me.