TherionSaysWhat wrote:
I use Dominos as a bar mod but when I first went to a non-standard UI it was just experimentation really. Download some add-ons and try out different layouts and whatnot. Your UI depends entirely on how you play and interact with the game. So there's really no "best" way to do it except individually.
With WotLK I started with Dominos, worked well, but after trying Bartender4 I was blown away. IMO either is WIN.
Now as for target frames, X-Perl is the all-in-one solution.