i have multiple sets that do different things for me.
i have a set that is based purely around stam, all stam gems, all stam enchants
i have a set that is based purely around avoidance, for bosses like Tidewalker in SSC (for an example, or Prince in Kara) its all enchanted with Dodge, gemed with dodge and the stats built around dodge / parry
i have a threat set, i mix in + hit, and shield blocking stats, so my shield slams and damage is way up (that set im not at 490 defense at the moment, but its geared around making as much threat as possible, and i dont use it for boss fights)