What are you trying to do?
Tanking will require a 1 hander and a shield, most healing also works this way. Killing things 1 at a time (ie. questing or any situation where you want to do lots of damage to a single thing) goes smoother with a 2 hander. Killing several things at once in melee combat goes much smoother with a 1 hander and shield.
You ask for suggestions.. all I can say is, try things out a few different ways. What have you got to lose? The time it takes to level up a weapon skill and possibly repec costs if you're already 70?