Bind the important stuff where ever you can reach them, and where they are comfortable to you. I here of people binding 1-5, QERTYFGH, along with alt/shift/control modifiers. I can't do that, my hands are too small and I'm used to playing with both turn and strafe keybound, so I bind everything to 234 RTF with shift and control modifiers. It means I click more often on some things, but that's not a problem for me.
In short: figure it out for yourself.