I run along the same lines as Mike does, except I have pretty much all of my major abilites bound to my mouse/mousewheel with shift/ctr/alt modifiers.
The only things that I have on my keyboard anymore are, premed,prep,ShS,thistle tea, kick and sprint and of course my movement with A and D set up as strafe and I use my mouse to turn.
Definately takes some time to get used to and remember where everything is, but it's way more effective.
EonSprinter wrote a nice keybinding faq and you can find it
Here **Edit for spelling Eon's name wrong.
Edited, Apr 13th 2008 8:00pm by FinalMeat