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This is rather apparent in Auchenai Crypts against Shirrak the Dead Watcher who has an AOE debuff that increase your cast time and stacks multiple times.
It's funny you mention this. I ran that instance for the first time yesterday (I'm a lvl 67 Holy Pally), and.....oh man. I never felt so useless in a group. We wiped a few times, and then gave up.
Of course, that is the first time I've really had any issues, so I wouldn't make any generalizations on it.