It's pretty easy to approximate your DPS increase from Lethality versus Imp. Poisons. We'll say Imp. Poisons only effects Instant Poison applied to your offhand. We'll say you have a 1.5 speed offhand with 0 misses and 0 instant attacks. Instant poison averages 170 damage per hit.
Poison DPS:
0/5 Imp. Poisons == 170 * .2 / 1.5 == 22.666 DPS
5/5 Imp. Poisons == 170 * .3 / 1.5 == 34 DPS
So, a 11.333 DPS increase for Imp. Poisons. This will decrease once you factor in misses and dodges. What about Lethality? Well, it will depend on your AP and crit. We'll say you've got 22% crit for a Sword build, 27% for Daggers, and 1500 AP. Your weapons will be the Season 1 Gladiator stuff. Easy early raid stats.
SS Damage:
(237 + 98 + 1500/14 * 2.4) * 1.06 * 1.10 == 690
((237 + 98 + 1500/14 * 2.4) * 1.06 * 1.10) * 2 == 1380
((237 + 98 + 1500/14 * 2.4) * 1.06 * 1.10) * 2.3 == 1588
0/5 Lethality == 690 * .22 + 1380 * .78 == 1228
5/5 Lethality == 690 * .22 + 1588 * .78 == 1390
So, how often do we use SS? We'll use the 2S/5R cycle. We'll say all energy is spent on nothing but this and that we have 0/3 Ruthlessness (too lazy to model that, it will cause the SS DPS we calculate to be a bit off).
So, how much energy do we need? We start with two SSes, that's 80, then a Slice and Dice. It will cost 25 * .6 (to factor Relentless in), or 15 energy, so that's 95. Now we need 5 more SSes, for another 200, then an essentially free Rupture, but we still have to wait on the tick. We'll assume we start from 25 energy since we should have followed a 5 point Rupture. 80 + 15 + 200 + 25 - 25 == 295, or 15 ticks. So, this cycle takes 30 seconds to complete (if we ignore Combat Potency). We also have 7 SSes in this 7 second period. So, now we can calculate our DPS from SS.
0/5 Lethality == 1228 * 7 / 30 == 286.5
5/5 Lethality == 1390 * 7 / 30 == 324.3
So, without Ruthlessness, we've got about a 38 DPS increase with Lethality. Let's try an upper bound to see what Ruthlessness could do. We'll be doing two fewer SSes, and need 80 less energy.
0/5 Lethality == 1228 * 5 / 22 == 279
5/5 Lethality == 1390 * 5 / 22 == 316
And that's a 37 DPS increase. To be honest, I'm not sure why the spreadsheet is saying you get more DPS from Imp. Poisons. I figured I'd see results about like this. Lethality scales to your gear, Imp. Poisons does not. Instant attacks are a large portion of your DPS, poisons are not. The better your gear gets, the bigger the gap gets. At relatively low gear levels with very poor crit, I could see Imp. Poisons winning out. In a raid situation when you're probably going to have ~2000 AP and 30-40% crit, Lethality is going to win by a landslide.
Edit: Just remembered that I didn't factor in SnD, but 30% haste isn't going to give the 200% boost to poison DPS required to overtake Lethality.
Edited, Oct 3rd 2007 8:27am by Nooblestick