Make sure you have the mob targeted, and click on your Melee Attack button. It it says you are too far away get closer. Also, to make other hotkeys, Click on the EQ button, go to actions, and click on Actions Window. An Actions Window will appear on your screen. From the Actions Window you can click on the Combat Tab, then right click on an empty box. There will be combat skills in there that you can use. Click on a skill and it goes into the window. Now left click on the Skill Button you just made, HOLD the left click down until the little block is on your cursor. Then drop the block onto an empty spot on your hotkeys bar. Do the same with the Abilities Page, checking to see what abilities are available to you. Then you can do the same with the Social tab. There are some social keys already made. You can switch to the next tab to make some of your own.
To make your own, right click on an empty block on the social tab, type in a name of it. Then make a macro with the info that you need. For example, a basic button is an Assist key. Right click on an empty social box. Type Assist in the Social Name. On the first line type /assist. Click the Accept box at the bottom right, and then click and hold the left mouse button on hotkey you just made. Move it to your hotkey bar. Now if you are targeted on someone and want to help them, you just click the Assist key you just made, and you will retarget the mob they are targeted on and you can nuke away.
The Tutorial is great for learning. Follow it along and you will get some gear, some spells, and some experience. You can also buy spells there for cheap.
Hope this helps a little.