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One question on nuking, if chanter has the mana (often due if we have bard or necro in group), I will cast Anarchy spell when mob is down to 40% or below - looking at the posts it looks like I could safely cast sooner? Appreciate any input on when to nuke to avoid pulling agro on chanter.
When exactly you can nuke depends on a lot of things. Had you mezzed the mob earlier? If so, that delays when you can nuke without aggo. Is your MT using proc weapons or not? If MT is a casting melee, have they done any casting? Its one of those things where you really have to work with the group a bit to get a sense of how well the MT keeps aggro.
On the flipside of that though is the question: Do you really WANT to nuke more than once? I don't know how many times I've been in a group with nuke-happy casters and ended up wiped because when the **** hit the fan, the casters went oom fast. They hadn't kept mana in reserve for emergencies.
My personal opinion is that for Cleric and Chanter, I'd rather seem them as close to FM as possible at all times, never going below about 50%-60% mana except in emergencies.
Even with a cleric in the group, I still like to see secondary healing classes (druids/shamans) always keep at least 25-50% mana in reserve for emergency healing. It may seem silly when you've been in the same camp single pulling for two hours without breaking a sweat but, crap happens and you never know when you'll have a pile of mobs descending on you unannouced.